ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE

ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE - Names and Identifiers

Name	ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE
Synonyms	ETHYL DIFLUORO(PYRIDIN-2-YL)ACETATE ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE Ethyl 2,2-Difluoro-2-(pyridin-2-yl)acetate 2-(1,1-Difluoro-2-ethoxy-2-oxoethyl)pyridine Difluoro(pyridin-2-yl)acetic acid ethyl ester 2-Pyridineacetic acid, a,a-difluoro-, ethyl ester 2,2-difluoro-2-(2-pyridinyl)acetic acid ethyl ester
CAS	267876-28-8

ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE - Physico-chemical Properties

Molecular Formula	C9H9F2NO2
Molar Mass	201.17
Density	1.228±0.06 g/cm3(Predicted)
Boling Point	244.2±35.0 °C(Predicted)
pKa	1.80±0.12(Predicted)
Storage Condition	2-8°C

ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE - Risk and Safety

Hazard Symbols

F - Flammable

ETHYL 2,2-DIFLUORO-2-(2-PYRIDYL)ACETATE - Introduction

ETHYL 2,2-difluoro-2-(2-PYRIDYL)ACETATE is a chemical compound with the chemical formula C9H8F2O2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Solubility: Soluble in organic solvents such as ethanol, ether and dichloromethane
-Melting point:-32 ° C
-Boiling point: 113-114 ° C
-Density: 1.235g/cm3
-Stability: stable at room temperature, but avoid prolonged contact with air and water

Use:
- ETHYL 2,2-difluoro-2-(2-PYRIDYL)ACETATE is commonly used as a reagent in organic synthesis, especially suitable for catalyzing the polysubstitution reaction of aromatic compounds. It can be used as an esterification and acylation reagent in organic synthesis.
-It can also be used in the fields of pesticides and medicines as an important intermediate.

Method:
- ETHYL 2,2-difluoro-2-(2-PYRIDYL)ACETATE can be synthesized by the following steps:
1. First, fluoroacetophenone and difluoromethylpyridine are reacted in diethyl carbonate or dichloromethane to produce 2-(2-pyridyl)-2-acetophenone.
2. Then, 2-(2-pyridyl)-2-acetophenone is reacted with acid chloride to generate 2,2-difluoro -2-(2-pyridyl) acetate.
3. Finally, the resulting 2,2-difluoro -2-(2-PYRIDYL)ACETATE is reacted with an alcohol to give ETHYL 2,2-difluoro-2-(2-PYRIDYL)ACETATE.

Safety Information:
- ETHYL 2,2-difluoro-2-(2-PYRIDYL)ACETATE is generally a safe compound under normal conditions of use. However, like all chemical substances, the following safety measures should be taken when using:
-Must operate in a well-ventilated place to avoid inhaling its vapor;
-Avoid contact with skin and eyes to avoid irritation;
-Seek immediate medical help if swallowed or other physical contact occurs;
-Should be stored properly, away from fire and flammable materials.

Please ensure that proper laboratory safety procedures are followed when using this compound and that relevant regulations and guidelines are followed.

Last Update：2024-04-09 21:01:54